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Ketamine is a versatile medication with a rich history, originally developed as an anesthetic in the 1960s.

Beyond its conventional use in surgery and emergency medicine, ketamine has gained recognition for its efficacy in various psychiatric and non-opioid pain management applications.

One notable therapeutic use is its role in treating depression, particularly in cases resistant to traditional antidepressants. The unique aspect of ketamine therapy lies in its ability to induce rapid and robust antidepressant effects, often within hours, providing a potential breakthrough for individuals experiencing severe depressive disorders.


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In recent years, alternative administration routes for ketamine have emerged, offering more options for both medical professionals and patients.

Intranasal ketamine, administered through the nasal mucosa, has gained popularity for its ease of use and potential to facilitate at-home treatments. This method allows for a more gradual and controlled release of the medication, making it suitable for patients who may not be comfortable with intravenous administration or those seeking a less-invasive option. The intranasal approach has shown promise in maintaining the therapeutic benefits of ketamine, making it a valuable addition to the arsenal of treatments available for mental health disorders.

Topical ketamine formulations have also been explored for their potential in managing localized pain. With the application of ketamine directly to the skin, these formulations may offer targeted relief for conditions such as neuropathic pain or complex regional pain syndrome.

 The localized application minimizes systemic absorption, reducing the risk of side effects associated with higher doses. This method showcases ketamine's adaptability in addressing various types of pain, providing a tailored solution for patients with specific needs.

Additionally, troches or lozenges present another avenue for ketamine administration. Troches dissolve slowly in the mouth, allowing for sublingual absorption and a controlled release of the medication. This method is convenient and may enhance patient compliance while providing an effective means of delivering therapeutic doses of ketamine. Troches offer a promising option for those seeking an alternative to traditional oral or injectable forms of medication, contributing to the expanding application of ketamine therapy in modern medicine.